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KMID : 0385920080190020185
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Journal of the Korean Society of Emergency Medicine
2008 Volume.19 No. 2 p.185 ~ p.191
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The Usefulness of Serum S-100 ββ Levels as a Screening Test for Pediatric Minor Head Trauma
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Park Hyun-Wook
Sung Won-Young
Lee Jang-Young
Kim Ji-Myung
Hong Sung-Yeup
Yang Young-Mo
Yi Hwa-Yeon
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Abstract
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Purpose: It is well known that serum S-100 βprotein levels increased in adults after brain injury. However, there is no definite clinical data in children with isolated minor head trauma. The present study was conducted to validate S-100 β
protein levels as a screening test for brain damage in children with minor head trauma.
Methods: Serum S-100 βprotein levels were measured in 48 pediatric patients with minor head trauma. All patients had brain computed tomography (CT) scan to confirm brain injury. Data were analyzed using a contingency table and a receiver operating characteristic (ROC) curve to determine the diagnostic value of S-100 βprotein levels.
Results: Twelve (25%) patients had abnormal brain CT findings. Using a concentration cutoff value of 0.12 ug/L,
patients with abnormal brain CT findings were identified by S-100 βprotein levels measurement with a sensitivity level
of 100% and a specificity 38.9%. The area under the ROC curve for S-100 βprotein levels was 0.758 (95% CI, 0.606- 0.910). The number of high risk factors were 2.35±1.23 in the positive group and 1.53±0.76 in the negative group (p=0.011).
Conclusion: Serum S-100 βprotein levels in children with minor head trauma were similar to those of adults. Our study supports the contention that rapid assessment of serum S-100 βprotein levels may reduce the use of brain CT in children with minor head trauma.
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KEYWORD
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S100 Proteins, Tomography, Head Injuries, Closed, Pediatrics
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